Impaired Renal Function and Biomarkers of Vascular Disease in Alzheimer's Disease

Cassandra Richardson, Ramin Nilforooshan, Paul Gard, Gary Weaving, Naji Tabet

Research output: Contribution to journalArticle

Abstract

Abstract: Renal disease is a risk factor for vascular diseases and for dementia, and renal insufficiency can be a feature of Alzheimer's disease (AD). Evidence has suggested that vascular mechanisms mediate the link between renal disease and dementia. Our study sought to test this hypothesis by examining renal and vascular functioning in AD by investigating estimated glomerular filtration rates (eGFR), calculated from serum creatinine concentrations, and established biomarkers of vascular functioning, asymmetrical dimethylarginine (ADMA) and plasma homocysteine (Hcy), in individuals with mild to moderate AD (n = 34) and a group of older adult controls (n = 34). We found significantly reduced eGFR, indicative of impaired renal functioning, in individuals with AD (M = 62.9, SD = 15.2) compared with controls (M = 73.6, SD = 11.8). However, concentrations of ADMA and Hcy did not differ between patient and control groups (ADMA: M = 0.47; M = 0.50; Hcy: M = 17.2; M = 14.9; patients and controls). The criteria for a mediation analysis were not met, as concentrations of ADMA and Hcy did not predict AD, indicating that these biomarkers of vascular functioning did not mediate a relationship between renal functioning and AD. This study indicated that renal insufficiency may independently contribute to AD pathology, and other vascular mechanisms may influence a relationship between renal impairment and AD.
Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalCurrent Alzheimer Research
Volume11
Issue number3
DOIs
Publication statusPublished - 31 Mar 2014

Bibliographical note

© 2014 Bentham Science Publishers

Keywords

  • Alzheimer's disease
  • asymmetrical dimethylarginine
  • biomarkers of vascular disease
  • glomerular filtration rate
  • homocysteine
  • renal disease

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