This is the second significant dataset to document the incidence of injury in a Summer Paralympic Games setting. Pre-competition injury rates were significantly higher than competition injury rates. The sports of football 5-a-side, judo and football 7-a-side had a significantly higher incidence of injury, compared to all other sports, whilst boccia and Para swimming had a significantly lower injury rate. The shoulder joint was the most commonly injured anatomical area. Acute injuries constituted the highest injury rate at the Games.