Abstract
Treatment of neonatal rat islets of Langerhans with combined cytokines (interleukin-1beta 10(-10) M, tumour necrosis factor-alpha 10(-10) M, interferon-gamma 5 U/ml) led to extensive cell death, which was potentiated by Fas activation with the anti-Fas cytolytic antibody JO2. Pre-treatment with insulin (25 ng/ml) or insulin-like growth factor-1 (10(-8)M) gave only partial protection against cell killing, but prevented the Fas-mediated component. In the absence of cytokine treatment, Fas-mediated killing was not observed.
Original language | English |
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Pages (from-to) | 207-210 |
Number of pages | 4 |
Journal | Febs Letters |
Volume | 435 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 18 Sept 1998 |
Bibliographical note
© 1998 Federation of European Biochemical Societies.Keywords
- Growth factor
- Cytokine
- Fas
- Apoptosis
- Islet of Langerhans