Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas

Moira Harrison, A.M. Dunger, S. Berg, Jon Mabley, N. John, M.H.L. Green, I.C. Green

Research output: Contribution to journalArticle

Abstract

Treatment of neonatal rat islets of Langerhans with combined cytokines (interleukin-1beta 10(-10) M, tumour necrosis factor-alpha 10(-10) M, interferon-gamma 5 U/ml) led to extensive cell death, which was potentiated by Fas activation with the anti-Fas cytolytic antibody JO2. Pre-treatment with insulin (25 ng/ml) or insulin-like growth factor-1 (10(-8)M) gave only partial protection against cell killing, but prevented the Fas-mediated component. In the absence of cytokine treatment, Fas-mediated killing was not observed.
Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalFebs Letters
Volume435
Issue number2-3
DOIs
Publication statusPublished - 18 Sep 1998

Bibliographical note

© 1998 Federation of European Biochemical Societies.

Keywords

  • Growth factor
  • Cytokine
  • Fas
  • Apoptosis
  • Islet of Langerhans

Fingerprint Dive into the research topics of 'Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas'. Together they form a unique fingerprint.

  • Cite this