GHMP kinases - Structures, mechanisms and potential for therapeutically relevant inhibition

Keyphrases

• GHMP Kinase 100%
• Kinase Structure 100%
• Mevalonate Kinase 60%
• Galactokinase 40%
• Homoserine Kinase 40%
• Mevalonate Diphosphate Decarboxylase 40%
• Methyl 20%
• Small Molecules 20%
• Caenorhabditis Elegans 20%
• Structural Information 20%
• Phosphate 20%
• Proton 20%
• Early Development 20%
• Active Sites 20%
• Mechanistic Data 20%
• Galactosemia 20%
• Saccharomyces Cerevisiae 20%
• Catalytic Mechanism 20%
• Phosphomevalonate Kinase 20%
• Aspartate 20%
• N-acetylgalactosamine 20%
• MgATP 20%
• Catalytic Base 20%
• Arabinose 20%
• Transcriptional Repressor 20%
• Related Family 20%
• Novel Antimicrobial Therapies 20%
• Transition State Stabilization 20%
• Erythritol 20%
• Cytidine 20%
• Shikimate Kinase 20%
• Chemotherapeutic Interventions 20%
• Cholesterol Biosynthesis Pathway 20%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 83%
• Mevalonate Kinase 66%
• Galactokinase 33%
• Pyrophosphate 33%
• Carboxy-Lyases 33%
• Enzyme 16%
• Caenorhabditis Elegans 16%
• Small Molecule 16%
• Saccharomyces cerevisiae 16%
• Active Site 16%
• Catalytic Mechanism 16%
• N-Acetylgalactosamine 16%
• Arabinose 16%
• Transcriptional Activator 16%
• Erythritol 16%
• Cytidine 16%
• Cholesterol Synthesis 16%