Faecal interleukin-8 and tumour necrosis factor-α concentrations in cystic fibrosis

G. L. Briars, T. P. Dean, J. L. Murphy, C. J. Rolles, J. O. Warner

Research output: Contribution to journalArticle

Abstract

Interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α) concentrations were measured in faecal samples from nine patients with cystic fibrosis and nine healthy age matched controls. The patients were assessed with Shwachman score, apparent energy absorption, pancreatic enzyme dosage, simple spirometry, and presence of pseudomonal colonisation. Median (range) wet stool IL-8 and TNF-α concentrations in patients were 32113 pg/g (21656-178128) and 3187 pg/g (368-17611) respectively, compared with <43.5 pg (IL-8)/g (<22-4079) and 99 pg (TNF-α)/g (<0.26-231) in controls. IL-8 concentration was negatively correlated with Shwachman score (r=-0.79) and pancreatic enzyme dosage (r=-0.77), but not with energy absorption. Seven patients were mature enough to cooperate with Their IL-8 concentrations with percentage predicted forced expiratory volume in one second (r=-0.78). IL-8 concentration was greater in four patients with, than five without, established pseudomonal colonisation: median difference 134583 pg/g. TNF-α concentration was not correlated with measures of disease severity. Faecal IL-8 concentration might reflect the severity of pulmonary inflammation in cystic fibrosis and could provide an easily obtainable marker of disease activity.

Original languageEnglish
Pages (from-to)74-76
Number of pages3
JournalArchives of Disease in Childhood
Volume73
Issue number1
DOIs
Publication statusPublished - 1 Jan 1995

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Interleukin-8
Cystic Fibrosis
Tumor Necrosis Factor-alpha
Spirometry
Forced Expiratory Volume
Enzymes
Pneumonia

Keywords

  • Cystic fibrosis
  • Interleukin-8
  • Tumour necrosis factor-α

Cite this

Briars, G. L. ; Dean, T. P. ; Murphy, J. L. ; Rolles, C. J. ; Warner, J. O. / Faecal interleukin-8 and tumour necrosis factor-α concentrations in cystic fibrosis. In: Archives of Disease in Childhood. 1995 ; Vol. 73, No. 1. pp. 74-76.
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Faecal interleukin-8 and tumour necrosis factor-α concentrations in cystic fibrosis. / Briars, G. L.; Dean, T. P.; Murphy, J. L.; Rolles, C. J.; Warner, J. O.

In: Archives of Disease in Childhood, Vol. 73, No. 1, 01.01.1995, p. 74-76.

Research output: Contribution to journalArticle

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