Effect of stretch combined with electrical stimulation on the type of sarcomeres produced at the ends of muscle fibers

Pamela Williams, Peter Watt, V. Bicik, Geoffrey Goldspink

Research output: Contribution to journalArticlepeer-review

Abstract

Stretching a muscle results in a rapid addition of sarcomeres at the ends of the muscle fibers. The effect of a pattern of electrical stimulation resembling that of a slow motoneuron on the newly formed muscle tissue in a stretched, fast-contracting muscle was investigated. We found that after a period as short as 4 days, the type of sarcomeres which were added on to the ends of the existing myofibrils differed from those in the middle regions of the experimental muscles: there was a much higher proportion of type I and type IIA sarcomeres in the stretch-stimulated ends. This study showed that reprogramming of the synthesis of fiber type-specific contractile proteins can be achieved and detected within a very short time by using electrical stimulation combined with stretch.

Original languageEnglish
Pages (from-to)500-509
Number of pages10
JournalExperimental Neurology
Volume93
Issue number3
DOIs
Publication statusPublished - 1 Jan 1986

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