Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism

Vasiliki Lagou, Yannis Manios, C.N. Moran, Mark E.S. Bailey, Evangelia Grammatikaki, E. Oikonomou, E. Ioannou, G. Moschonis, R.H. Wilson, Yannis Pitsiladis

Research output: Contribution to journalArticle

Abstract

OBJECTIVES To investigate the relationship between the angiotensin I-converting enzyme 1 (ACE) I/D polymorphism and adiposity-related phenotypes in a large cohort of toddlers and preschoolers. METHODS Body composition measurements and DNA samples were obtained from 2102 Greek children aged 1-6 years, as part of a large-scale epidemiological study (GENESIS). All children were genotyped for the ACE I/D polymorphism and gender- and age-stratified statistical analyses were performed. RESULTS In girls aged 4-6 years, the D-allele was associated with higher measurements of body mass index (BMI) (P=0.018), waist (P=0.001) and upper arm (P=0.013) circumferences, genotype accounting for 2.5, 4 and 3% of the phenotypic variance, respectively. In boys, the D-allele showed strong associations with lower BMI (P=0.001) at the age of 1-2 years that explained 17% of the phenotypic variance and with larger suprailiac skinfold (P=0.008) at 3-4 years old that explained 2% of the variance. No other significant associations between the ACE I/D polymorphism and adiposity-related phenotypes were found. In girls, the age at which significant associations were revealed coincided with the age at which BMI was observed to increase after its developmental nadir, but this feature of the association was not observed in boys. CONCLUSIONS The ACE I/D polymorphism is associated with developmental and physiological changes in adiposity-related traits during early childhood in a gender- and age-specific manner.
Original languageEnglish
Pages (from-to)1052-1060
Number of pages9
JournalInternational Journal of Obesity
Volume31
Issue number7
DOIs
Publication statusPublished - 31 Jul 2007

Keywords

  • ACE I/D polymorphism
  • association study
  • adiposity-related phenotypes
  • toddlers and preschoolers

Fingerprint Dive into the research topics of 'Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism'. Together they form a unique fingerprint.

  • Cite this

    Lagou, V., Manios, Y., Moran, C. N., Bailey, M. E. S., Grammatikaki, E., Oikonomou, E., Ioannou, E., Moschonis, G., Wilson, R. H., & Pitsiladis, Y. (2007). Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism. International Journal of Obesity, 31(7), 1052-1060. https://doi.org/10.1038/sj.ijo.0803605