Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors

C. Wignall, Thomas Tapmeier, Ruth Muschel, Annamaria Gal

Research output: Contribution to conferenceAbstract

Abstract

Macrophages can display various functional traits in the tumor microenvironment, depending on the tumor type and the stage of tumor progression. The polarized scheme of macrophage activation describes antitumoral (activation by INF-g) and protumoral (activation by IL-4) phenotypes. Tumor associated macrophages are attracted to the tumor by the combined effects of various factors, including chemokines. We investigated chemokine receptors CCR1, CCR2 and CCR5 in the directed migration of polarized macrophages, including a macrophage cell line, bone marrow derived macrophages and tumour associated macrophages of an experimental melanoma lung metastasis. Inhibiting chemokine receptors in lung colonization reduced the infiltration of both protumoral and antitumoral macrophages.
Original languageEnglish
Pages0-0
Number of pages1
Publication statusPublished - 15 Jun 2015
EventCell symposia: Cancer, inflammation and immunity - Sitges, Spain, 2015
Duration: 15 Jun 2015 → …

Conference

ConferenceCell symposia: Cancer, inflammation and immunity
Period15/06/15 → …

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Chemokine Receptors
Macrophages
Neoplasms
Lung
Experimental Melanomas
Tumor Microenvironment
Macrophage Activation
Chemokines
Interleukin-4
Neoplasm Metastasis
Phenotype
Cell Line

Cite this

Wignall, C., Tapmeier, T., Muschel, R., & Gal, A. (2015). Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors. 0-0. Abstract from Cell symposia: Cancer, inflammation and immunity, .
Wignall, C. ; Tapmeier, Thomas ; Muschel, Ruth ; Gal, Annamaria. / Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors. Abstract from Cell symposia: Cancer, inflammation and immunity, .1 p.
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Wignall, C, Tapmeier, T, Muschel, R & Gal, A 2015, 'Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors' Cell symposia: Cancer, inflammation and immunity, 15/06/15, pp. 0-0.

Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors. / Wignall, C.; Tapmeier, Thomas; Muschel, Ruth; Gal, Annamaria.

2015. 0-0 Abstract from Cell symposia: Cancer, inflammation and immunity, .

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors

AU - Wignall, C.

AU - Tapmeier, Thomas

AU - Muschel, Ruth

AU - Gal, Annamaria

PY - 2015/6/15

Y1 - 2015/6/15

N2 - Macrophages can display various functional traits in the tumor microenvironment, depending on the tumor type and the stage of tumor progression. The polarized scheme of macrophage activation describes antitumoral (activation by INF-g) and protumoral (activation by IL-4) phenotypes. Tumor associated macrophages are attracted to the tumor by the combined effects of various factors, including chemokines. We investigated chemokine receptors CCR1, CCR2 and CCR5 in the directed migration of polarized macrophages, including a macrophage cell line, bone marrow derived macrophages and tumour associated macrophages of an experimental melanoma lung metastasis. Inhibiting chemokine receptors in lung colonization reduced the infiltration of both protumoral and antitumoral macrophages.

AB - Macrophages can display various functional traits in the tumor microenvironment, depending on the tumor type and the stage of tumor progression. The polarized scheme of macrophage activation describes antitumoral (activation by INF-g) and protumoral (activation by IL-4) phenotypes. Tumor associated macrophages are attracted to the tumor by the combined effects of various factors, including chemokines. We investigated chemokine receptors CCR1, CCR2 and CCR5 in the directed migration of polarized macrophages, including a macrophage cell line, bone marrow derived macrophages and tumour associated macrophages of an experimental melanoma lung metastasis. Inhibiting chemokine receptors in lung colonization reduced the infiltration of both protumoral and antitumoral macrophages.

M3 - Abstract

SP - 0

EP - 0

ER -

Wignall C, Tapmeier T, Muschel R, Gal A. Comparison of antitumoral and protumoral macrophage migration by targeting differentially regulated chemokine receptors. 2015. Abstract from Cell symposia: Cancer, inflammation and immunity, .