Cancer gene therapy with targeted adenoviruses

Houria Bachtarzi, Mark Stevenson, Kerry Fisher

Research output: Contribution to journalArticle

Abstract

Clinical experience with adenovirus vectors has highlighted the need for improved delivery and targeting. Objectives: This manuscript aims to provide an overview of the techniques currently under development for improving adenovirus delivery to malignant cells in vivo. Methods: Primary research articles reporting improvements in adenoviral gene delivery are described. Strategies include genetic modification of viral coat proteins, non-genetic modifications including polymer encapsulation approaches and pharmacological interventions. Results/conclusion: reprogramming adenovirus tropism in vitro has been convincingly demonstrated using a range of genetic and physical strategies. These studies have provided new insights into our understanding of virology and the field is progressing. However, there are still some limitations that need special consideration before adenovirus-targeted cancer gene therapy emerges as a routine treatment in the clinical setting.
Original languageEnglish
Pages (from-to)1231-1240
Number of pages10
JournalExpert Opinion on Drug Delivery
Volume5
Issue number11
Publication statusPublished - 3 Nov 2008

Keywords

  • adenovirus
  • genetic modifications
  • gene therapy
  • polymer-coating
  • transductional targeting

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    Bachtarzi, H., Stevenson, M., & Fisher, K. (2008). Cancer gene therapy with targeted adenoviruses. Expert Opinion on Drug Delivery, 5(11), 1231-1240.