Arbitrary self-assembly of peptide extracellular microscopic matrices

Angelo Bella, Santanu Ray, Michael Shaw, Maxim G. Ryadnov

Research output: Contribution to journalArticle


Two faces for one matrix: A single bifaceted cyclopeptide block forms highly branched, porous, and intricate fibrillar networks, which span microscopic dimensions and mimic the extracellular matrix to support cell growth and proliferation (see picture). The peptide block has two domains connected with triglycine linkers (GGG); the domains consist of positively (blue) and negatively (red) charged heptads that provide interactions between different blocks.

Original languageEnglish
Pages (from-to)428-431
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number2
Publication statusPublished - 9 Jan 2012


  • cell adhesion
  • extracellular matrix
  • protein design
  • self-assembly
  • tissue engineering

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