Arbitrary self-assembly of peptide extracellular microscopic matrices

Angelo Bella, Santanu Ray, Michael Shaw, Maxim G. Ryadnov

    Research output: Contribution to journalArticlepeer-review


    Two faces for one matrix: A single bifaceted cyclopeptide block forms highly branched, porous, and intricate fibrillar networks, which span microscopic dimensions and mimic the extracellular matrix to support cell growth and proliferation (see picture). The peptide block has two domains connected with triglycine linkers (GGG); the domains consist of positively (blue) and negatively (red) charged heptads that provide interactions between different blocks.

    Original languageEnglish
    Pages (from-to)428-431
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Issue number2
    Publication statusPublished - 9 Jan 2012


    • cell adhesion
    • extracellular matrix
    • protein design
    • self-assembly
    • tissue engineering


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