A standard calculation methodology for human doubly labeled water studies

, John R. Speakman, Yosuke Yamada, Hiroyuki Sagayama, Elena S.F. Berman, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. CloseJamie A. Cooper, Seth A. Creasy, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Cara B. Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, David S. Ludwig, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, Yannis P. Pitsiladis

Research output: Contribution to journalArticlepeer-review


Speakman et al. use a large database of doubly labeled water measurements to show the choice of equation for the calculation of energy expenditure introduces significant variation into the final estimate. They then derive new equations that outperform previous equations in validation studies against chamber calorimetry.

Original languageEnglish
Article number100203
JournalCell Reports Medicine
Issue number2
Publication statusPublished - 16 Feb 2021

Bibliographical note

Funding Information:
The DLW database, which can be found at https://www.dlwdatabase.org/ , is generously supported by the IAEA (Vienna, Austria) , Taiyo Nippon Sanso , and SERCON . We are grateful to these companies for their support and especially to Takashi Oono for his tremendous efforts at fund raising on our behalf. The authors also gratefully acknowledge funding from the US National Science Foundation ( BCS-1824466 ) awarded to Herman Pontzer. The funders played no role in the content of this manuscript.

Publisher Copyright:
© 2021 The Authors

Copyright 2021 Elsevier B.V., All rights reserved.


  • doubly labeled water
  • free-living
  • total energy expenditure
  • validation


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