Extracellular Vesicle Profiling for early detection of leukaemic progression

Extracellular vesicles (EVs), cargo-carrying, lipid enclosed vesicles, are released by cancer cells into the circulation and are a potential biomarker for early detection of malignancy1. However, they can be ‘lost’ in the sea of normal EVs in the circulation; we therefore need a highly-scalable single-EV approach to detect the electrochemical signatures of EVs without a priori knowledge of the specific differences in intra-vesicular cargo.


This project will evaluate the suitability of single entity electrochemistry as a measurement tool for individual extracellular vesicles (EVs) to obtain a unique, cargo-agonistic fingerprint for early detection of leukaemic progression in a high-risk group.