Extracellular Vesicle Profiling for early detection of leukaemic progression

  • Carter, David, Oxford Brookes University, (PI)
  • Patel, Bhavik (PI)
  • Psaila, Bethan , University of Oxford, (CoI)
  • Turner, Nicholas, De Montfort University, (CoI)
  • Zhu, Tingting, University of Oxford, (CoI)

Description

Extracellular vesicles (EVs), cargo-carrying, lipid enclosed vesicles, are released by cancer cells into the circulation and are a potential biomarker for early detection of malignancy1. However, they can be ‘lost’ in the sea of normal EVs in the circulation; we therefore need a highly-scalable single-EV approach to detect the electrochemical signatures of EVs without a priori knowledge of the specific differences in intra-vesicular cargo.


This project will evaluate the suitability of single entity electrochemistry as a measurement tool for individual extracellular vesicles (EVs) to obtain a unique, cargo-agonistic fingerprint for early detection of leukaemic progression in a high-risk group.
Short titleExoPop
StatusActive
Effective start/end date1/12/1830/11/19