Evaluation of faecal pellet sensor device in inflammatory bowel disorder (IBD)

I proposed to undertake a 3 week visit to Prof Mawe’s laboratory to use the faecal pellet sensor (developed as part of the IMPRESS project award) and other sensing devices that have been developed by my group.

Our aim would be to understand how serotonin signalling and rectum motility are altered in animal models of IBD. We will conduct measurements to monitor the release of serotonin from animals that have had their lower digestive tracts inflamed using chemical agents such as 2,4,6-Trinitrobenzenesulfonic acid (TNBS) and dextran sodium sulphate (DSS). Measurements will be conducted using isolated tissue and attempted in vivo. Prof Mawe’s group have expertise in these animal models and conducting physiology evaluations in vitro and in vivo and therefore can provide exceptional insight into characterisation of our sensor devices.