Project Details

Description

Small cells present in the lining of the gastrointestinal tract (colonic mucosa) called enterochromaffin (EC) cells have been shown to be involved in regulating the motility of the lower bowel.

As bowel motility is impaired in older people, the project explored whether this was due to how the EC cells properties changed with increasing age and whether any changes were linked to altered motility.

Key findings

We were able to successfully isolate EC cells from young samples of colonic mucosa and while we were able to isolate EC cells from old colon samples this was not as successful as the young and requires further development to enable enough cells to be isolated to perform relevant analysis.
StatusFinished
Effective start/end date1/08/1131/07/14

Funding

  • BBSRC