The role of the exoribonuclease Pacman/Xrn1 in wing development in Drosophila

  • Joseph Alexander Waldron

Student thesis: Doctoral Thesis


RNA stability plays a critical role in the control of gene regulation by determining the levels of mRNA that can be translated into protein. The aim of this thesis is to investigate the role of the exoribonuclease Pacman in regulating gene expression during wing development in Drosophila melanogaster. Pacman is the only known cytoplasmic exoribonuclease which degrades RNA in a 5’‐3’ direction and is highly conserved across all eukaryotes.
Date of AwardDec 2014
Original languageEnglish
Awarding Institution
  • University of Brighton

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