RNA stability plays a critical role in the control of gene regulation by determining the levels
of mRNA that can be translated into protein. The aim of this thesis is to investigate the role
of the exoribonuclease Pacman in regulating gene expression during wing development in
Drosophila melanogaster. Pacman is the only known cytoplasmic exoribonuclease which
degrades RNA in a 5’‐3’ direction and is highly conserved across all eukaryotes.
|Date of Award||Dec 2014|