The role of hypertension and inflammation on the cognitive symptoms of Alzheimer’s disease patients

  • Lucy Nelson

Student thesis: Doctoral Thesis


Background This study aimed to assess the effect of blood pressure and inflammation on the cognitive symptoms of mild Alzheimer’s disease (AD) patients. Mid-life high blood pressure is known to be a risk factor for dementia, whereas low blood pressure in older age associates with poorer cognitive performance. Increased inflammation is also associated with the development of AD, and so this study assessed the impact of both blood pressure and inflammation on individual cognitive symptoms within AD patients. The possible synergistic effect of blood pressure, markers of vascular health asymmetric dimethylarginine (ADMA) and Fetuin-A, and markers of inflammation upon cognition was also assessed.
Date of AwardMay 2016
Original languageEnglish
Awarding Institution
  • University of Brighton

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