The role of hypertension and inflammation on the cognitive symptoms of Alzheimer’s disease patients

Abstract

Background This study aimed to assess the effect of blood pressure and inflammation on the cognitive symptoms of mild Alzheimer’s disease (AD) patients. Mid-life high blood pressure is known to be a risk factor for dementia, whereas low blood pressure in older age associates with poorer cognitive performance. Increased inflammation is also associated with the development of AD, and so this study assessed the impact of both blood pressure and inflammation on individual cognitive symptoms within AD patients. The possible synergistic effect of blood pressure, markers of vascular health asymmetric dimethylarginine (ADMA) and Fetuin-A, and markers of inflammation upon cognition was also assessed.

Date of Award	May 2016
Original language	English
Awarding Institution	University of Brighton