The success of Highly Active Anti-Retroviral Therapy (HAART) requires a high rate of
adherence to a complex regimen. Even small variations in adherence compromise treatment
efficacy and can lead to viral resistance. Low levels of adherence to HAART continue to pose
a major barrier to the success of these treatments. Studies investigating adherence to HAART
have focused on practical barriers, yet studies in other illness groups suggest that patients'
perceptions of their illness and treatment have a strong influence.
This thesis is concerned with furthering our understanding of non-adherence to HAART. It
begins with a review of HIV and its treatment. A critical review of the literature was conducted
using systematic techniques. This identifies outstanding questions relating to the antecedents
of adherence to HAART.
The aim of this investigation was primarily to test the Self-Regulatory Model (SRM) and
extensions to it to incorporate treatment perceptions (perceptions of personal necessity for
HAART and concerns about adverse effects) in predicting adherence to HAART.
|Date of Award||Jul 2004|