The metabolic and functional consequences of hyperammonaemia

  • Daniel James Wilkinson

Student thesis: Doctoral Thesis


Ammonia is an essential intermediate of a number of metabolic pathways in the body, from the maintenance of normal brain function, efficient immune response, to the production of energy within muscle cells to maintain contraction during exercise. However, ammonia levels must be carefully maintained within a low concentration range (no greater than 50-100╬╝mol/L), or toxicity may develop. Excess ammonia, also known as hyperammonaemia, has been linked to the development of neurological dysfunction in liver disease states and certain in-born genetic metabolic defects (e.g. urea cycle enzyme deficiencies), whilst it is also believed to impair the regulation of protein metabolism in a number of tissues.
Date of AwardJun 2012
Original languageEnglish
Awarding Institution
  • University of Brighton

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