Many conventional biomaterials fail to meet the demands required of them with
respect to their surface and bulk properties. This problem can be addressed by
developing novel biomaterials that have the desired bulk properties and increased
biocompatibility. Alternatively the surfaces of biomaterials which have the desired
bulk properties can be modified to increase their biocompatibility without
compromising these bulk properties. Phosphorylcholine (PC) based coatings mimic
the surface of biological membranes and so offer a novel method for modifying bulk
materials, or can be incorporated into novel bulk biomaterials. One of the key issues
of biocompatibility is the continual stimulation of the inflammatory response by
biomaterials characterised in part by complement activation, macrophage adhesion
and granulocyte activation.
Date of Award | 2001 |
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Original language | English |
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Awarding Institution | |
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The biocompatibility of novel phosphorylcholine based biomaterials
Barraud, J. E. (Author). 2001
Student thesis: Doctoral Thesis