Selective serotonin reuptake inhibitors and tricyclic antidepressants: novel immunomodulating agents

  • Sevelanne Gordon

Student thesis: Doctoral Thesis


Acute respiratory distress syndrome (ARDS) is an inflammatory disease in humans where no satisfactory therapeutic options exist. Regulation of the immune system by neurotransmitters has been identified as a possible exploitable strategy to treat inflammatory conditions. Antidepressant drugs have been found to have secondary actions including anti-inflammatory activity in a wide range of disease states in vivo. The cellular effects of these drugs that contribute to this effect have yet to be elucidated. The aim was to examine whether anti-depressants have a direct effect on the immune system or an effect on the target tissue such as lung cells.
Date of AwardFeb 2012
Original languageEnglish
Awarding Institution
  • University of Brighton

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