Redox regulation of inflammation and immunity

  • Sonia Salzano

Student thesis: Doctoral Thesis


Inflammation is a consequence of the activation of innate immunity and represents an important component of several pathological conditions, including not only the complication of infections but also sterile and autoimmune diseases. An early event in inflammation is represented by the production of proinflammatory cytokines and both their production and action have often been associated to oxidative stress. The redox status of the cell is therefore a key regulator of inflammation and glutathionylation (formation of mixed disulphides between cysteine residues of proteins and glutathione) is considered an important mechanism of this regulation.
Date of AwardOct 2013
Original languageEnglish
Awarding Institution
  • University of Brighton

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