Protection of pancreatic beta cells by rosiglitazone - mechanisms and pathways

  • Tomader Faroug Mohammed Ali

Student thesis: Doctoral Thesis


The thiazolidinedione Rosiglitazone can protect pancreatic beta cells from the detrimental effects of free fatty acids. The aim of this study was to determine the differential effects of saturated fatty acids on beta cells and to identify the mechanisms through which Rosiglitazone can protect beta cell viability. Utilising the mouse beta cell line MIN6, transmission electron microscopy (TEM) was used to determine the effects of palmitate and Rosiglitazone on lipid uptake and cell ultra-structure. H/PI staining and MTT assays were used to determine cell viability.
Date of AwardAug 2011
Original languageEnglish
Awarding Institution
  • University of Brighton

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