Poly-ɛ-lysine dendron aptamers as regulators of angiogenesis in tissue regeneration

Abstract

The successful regeneration of damaged or injured tissues is strictly dependent upon the ability to control angiogenesis. The formation of new blood vessels from pre-existing ones is mainly regulated by the vascular endothelial growth factor (VEGF), a mitogen specific for endothelial cells. A number of therapeutic approaches are being pursued to control this process in pathological conditions, including the use of synthetic peptides which have shown their capacity to either promote or inhibit angiogenesis. However, their lack of stability and short half-lives have strictly limited their clinical applications. To address these limitations, here, both anti- and pro- angiogenic peptide sequences (WHLPFKC and YIGSR) were synthesised at the uppermost branching generation of poly-ɛ-lysine dendrons.

Date of Award	Nov 2013
Original language	English
Awarding Institution	University of Brighton