Mechanisms of neuritis-induced C-fibre hyperexcitability: a role for nerve inflammation in chronic pain

Abstract

Patients with chronic pain conditions such as repetitive strain injury and complex regional pain syndrome frequently lack signs of a nerve injury on routine clinical examination. Evidence from the neuritis animal model suggests that painful symptoms could be generated from inflamed primary sensory neurons in the absence of gross pathological changes. In this model, nociceptive neurons develop signs of increased excitability. The aim of this project was to determine the mechanisms underlying neuritis-induced hyperexcitability, in particular C-fibre neuron ongoing activity.

Date of Award	2012
Original language	English
Awarding Institution	University of Brighton