Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)

  • Sabina Dizdarevic

Student thesis: Doctoral Thesis

Abstract

Tc-99m-MIBI is a substrate for ATP-binding cassette (ABC) transporter proteins, including P-glycoprotein (P-gp), and has been used to image their expression, mainly in cancer. Imaging P-gp expression may have a role in renal transplantation and investigating drug toxicity. The aim of the project was to develop a functional imaging assay for ABC-transporters using Tc-99m-MIBI.
Date of AwardMar 2015
Original languageEnglish
Awarding Institution
  • University of Brighton

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