Hypermobility and Autonomic Hyperactivity: Relevance for the Expression of Psychiatric Symptoms

  • Jessica Anne Eccles

Student thesis: Doctoral Thesis


The aim of this programme of work is to characterize the relevance of joint hypermobility and autonomic symptoms, particularly orthostatic intolerance, to clinical psychopathology. Joint hypermobility is a widespread, poorly recognized, connective tissue condition. Affected individuals are reportedly overrepresented among panic or anxiety disorders, irritable bowel syndrome, fibromyalgia, and chronic fatigue. Dysfunction or dysregulation of the autonomic nervous system, typically postural tachycardia syndrome is often found. Structural differences in amygdala have been reported in association with joint hypermobility. The relevance of hypermobility and autonomic dysfunction to general psychiatric conditions is currently poorly understood.
Date of AwardFeb 2016
Original languageEnglish
Awarding Institution
  • University of Brighton

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