Hydrogel microspheres for the treatment of tumours

  • Richard Edward John Forster

Student thesis: Doctoral Thesis


Embolic materials for the treatment of hypervasularised tumours are often non-degradable hydrogels. In this thesis alginate hydrogel microspheres were synthesised and tested as a potential biodegradable embolic agent. Degradation and compressibility were shown in vitro to be dependent on the mannuronic acid to L-guluronic acid ratio, which was attributed to the affinity of calcium to bind to the different alginate monomers. The microspheres were shown to be deliverable and compatible with non-ionic radiopaque contrast media.
Date of AwardJun 2009
Original languageEnglish
Awarding Institution
  • University of Brighton

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