Embolic materials for the treatment of hypervasularised tumours are often non-degradable
hydrogels. In this thesis alginate hydrogel microspheres were synthesised and tested as a
potential biodegradable embolic agent. Degradation and compressibility were shown in vitro to
be dependent on the mannuronic acid to L-guluronic acid ratio, which was attributed to the
affinity of calcium to bind to the different alginate monomers. The microspheres were shown
to be deliverable and compatible with non-ionic radiopaque contrast media.
|Date of Award||Jun 2009|