AbstractStrain differences have previously been observed in the anxiolytic effect of the Angiotensin Type I receptor (AT1 R) antagonist losartan in mice. Structural variation in key binding sites, AT1 receptor binding, AT1 expression, the effect of a microsatellite in the promoter region of the gene and the influence of angiotensin receptor associated protein (ATRAP) were investigated for association with this observed behavioural variation.
|Date of Award||2009|
Genetic variation underlying anxiety-like behaviour in laboratory mouse strains
Golding, B. J. D. (Author). 2009
Student thesis: Doctoral Thesis