Genetic variation underlying anxiety-like behaviour in laboratory mouse strains

  • Bruno J.D. Golding

Student thesis: Doctoral Thesis


Strain differences have previously been observed in the anxiolytic effect of the Angiotensin Type I receptor (AT1 R) antagonist losartan in mice. Structural variation in key binding sites, AT1 receptor binding, AT1 expression, the effect of a microsatellite in the promoter region of the gene and the influence of angiotensin receptor associated protein (ATRAP) were investigated for association with this observed behavioural variation.
Date of Award2009
Original languageEnglish
Awarding Institution
  • University of Brighton

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