Epigenetic regulation of amino acids metabolic genes defines targets of synthetic lethality in breast cancer

Abstract

Breast cancer is the second most common cause of death after lung cancer in developing countries. There is a great need to expand the range of biomarkers to identify patients that can be treated using new therapies. Epigenetic silencing of amino acid regulatory genes have been postulated as a predictive biomarker in breast cancer and treatment based on modulating amino acid levels have been shown to be effective in other cancers. In this study, I have examined how the amino acid regulatory genes for glutamine (Glutamine synthetase, GLUL) and arginine (Arginino-succinate synthetase, ASS1) synthesis are silenced via methylation in a panel of breast cancer cell lines.

Date of Award	Jun 2014
Original language	English
Awarding Institution	University of Brighton