Elucidation of porcine corneal ultrastructure to inform development of corneal xenographs or biomimetic replacements

  • Ashley Howkins

Student thesis: Doctoral Thesis


The transparent, anterior-most tissue of the eye globe, which allows light into the eye for sight, is the cornea. The main thickness of the cornea, known as the stroma, is a collagenous extra cellular matrix (ECM) that is comprised of fibrous collagen types I, V and VI along with keratan sulphate (KS) and chondroitin/dermatan sulphate (CS/DS) proteoglycans. These components maintain the collagen fibrils in a quasi-crystalline arrangement, which enables the tissue to be transparent.
Date of AwardJun 2015
Original languageEnglish
Awarding Institution
  • University of Brighton

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