This thesis investigates the relationship between quantitative correlates of diffuse brain damage and neurological and psychiatric manifestations in Systemic Lupus Erythematosus (SLE). A group of 37 patients with a primary diagnosis of SLE (mean age 43.97±12.55) were compared to 29 matched healthy controls. The SLE group were subdivided into those who had experienced neuropsychiatric (NP) manifestations (NPSLE – n=15) and those who had never had NP manifestations (non-NPSLE). Participants completed a broad cognitive test battery, neuropsychological measures and quantitative MRI (magnetisation transfer (MTI) and diffusion tensor imaging (DTI)). From MTI the magnetisation transfer ratio (MTR) was measured, which can be a marker for demyelination. Using DTI the extent (apparent diffusion coefficient) and directionality (fractional anisotropy) of diffusion were assessed, which are sensitive measures of brain structural integrity.
|Date of Award||2012|