Blood pressure, the brain, and quality of life in elderly people with chronic kidney disease

Abstract

Eighteen per cent of the UK population have cognitive impairment and 1/3 of older people have chronic kidney disease (CKD). There is a high prevalence of white coat hypertension (WCH) in this population. Observational studies have associated lower BP with poor cognitive function. In the CKD population lower BP has been associated with increased mortality and cardiovascular events. Lowering BP might adversely affect cognitive function. Aims: To describe associations between ambulatory blood pressure measurements (ABPM), white coat effect (WCE) and cognitive function and to determine if carotid atherosclerosis contributes to this association. Quantitative MRI will be used to analyse structural correlates for adverse cognitive performance and to ascertain if quality of life (HRQOL) is affected by lower ABPM.

Date of Award	Dec 2012
Original language	English
Awarding Institution	University of Brighton