Intravesical Bacillus Calmette–Guérin (BCG) immunotherapy is the main
treatment for bladder high-grade non-muscle invasive transitional cell carcinoma
(HGNMITCC) following initial resection. Unfortunately, about 30% of patients will not
respond to treatment and they carry a high risk of disease progression. The alternative,
radical cystectomy, has major risks with high morbidity and mortality. The ability to
predict the response to BCG treatment would be a useful tool in the selection of
appropriate treatment modalities. This study investigated a variety of detectable immune
responses in blood and urine to establish if there were differences between responders and
non-responders to BCG treatment. We evaluated whether there were detectable
immunological differences in blood or urine that could explain or predict outcome.
Date of Award | 2015 |
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Original language | English |
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Awarding Institution | |
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Biomedical markers of response to intravesical bcg treatment in high-grade non-muscle invasive (pta and pt1) transitional cell carcinoma of the bladder
Jallad, S. (Author). 2015
Student thesis: Doctoral Thesis