We can easily be left behind by the explosion in technological developments in medicine—or is it just a sign of getting older? Many of us will remember a time before MRI were readily available, and having to learn what fat suppressed images, T1s and T2s actually meant. Genomics is another example of a rapidly expanding technological develop- ment with major implications for medi- cine, and even experienced clinicians (many without formal training in molecu- lar biology) are struggling to understand this. It requires learning a whole new lan- guage. The sequencing of the 3.2 billion nucleotides that compose the human genome was first completed only in 2003, at an estimated cost of $2.7 billion. At the time, it was simply something of interest, unlikely to influence our working lives any time soon. Now, in just over a decade, it is possible to sequence the whole genome for $1000.