Tour de France champions born or made: where do we take the genetics of performance?

Colin N. Moran, Yannis Pitsiladis

Research output: Contribution to journalArticle

Abstract

Cyclists in the Tour de France are endurance specialists. Twin and family studies have shown that approximately 50% of the variance in a number of performance related phenotypes (whether measured at baseline, i.e. natural talent, or in response to training) including those important to cycling can be explained by genetic variation. Research into the specific genetic variants that are responsible has identified over 200 genes containing common genetic variants involved in the genetic predisposition to physical performance. However, typically these explain only a small portion of the variance, perhaps 1-2% and collectively they rarely explain anything approaching the 50% of the variance identified in the twin and family studies. Thus, there is a gap in our understanding of the relationship between heritability and performance. This gap may be bridged by investigation of rare variants or epigenetic variation or by altering study designs through increased collaborations to pool exiting cohorts together. Initial findings from such efforts show promising results. This mini-review will touch on the genetics and epigenetics of sporting performance, how they relate to cyclists in the Tour de France and where best future efforts may be directed as well as discuss some preliminary research findings.
Original languageEnglish
Pages (from-to)1411-1419
Number of pages9
JournalJournal of Sports Sciences
Volume35
Issue number14
DOIs
Publication statusPublished - 6 Aug 2016

Fingerprint

Twin Studies
Epigenomics
France
Aptitude
Genetic Predisposition to Disease
Research
Phenotype
Genes

Bibliographical note

This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Sports Sciences (ISSN: 0264-0414) on 06/08/2016 available online: http://www.tandfonline.com/[Article DOI 10.1080/02640414.2016.1215494

Keywords

  • Genetics
  • epigenetics
  • cyclists
  • elite athlete cohorts
  • PowerGene
  • GAMES
  • Athlome.

Cite this

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abstract = "Cyclists in the Tour de France are endurance specialists. Twin and family studies have shown that approximately 50{\%} of the variance in a number of performance related phenotypes (whether measured at baseline, i.e. natural talent, or in response to training) including those important to cycling can be explained by genetic variation. Research into the specific genetic variants that are responsible has identified over 200 genes containing common genetic variants involved in the genetic predisposition to physical performance. However, typically these explain only a small portion of the variance, perhaps 1-2{\%} and collectively they rarely explain anything approaching the 50{\%} of the variance identified in the twin and family studies. Thus, there is a gap in our understanding of the relationship between heritability and performance. This gap may be bridged by investigation of rare variants or epigenetic variation or by altering study designs through increased collaborations to pool exiting cohorts together. Initial findings from such efforts show promising results. This mini-review will touch on the genetics and epigenetics of sporting performance, how they relate to cyclists in the Tour de France and where best future efforts may be directed as well as discuss some preliminary research findings.",
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Tour de France champions born or made: where do we take the genetics of performance? / Moran, Colin N.; Pitsiladis, Yannis.

In: Journal of Sports Sciences, Vol. 35, No. 14, 06.08.2016, p. 1411-1419.

Research output: Contribution to journalArticle

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