Thermoregulation is not impaired in breast cancer survivors during moderate-intensity exercise performed in warm and hot environments

Rebecca Relf, Ben J. Lee, Gregor Eichhorn, Melanie Flint, Louisa Beale, Neil Maxwell

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study aimed to assess how female breast cancer survivors (BCS) respond physiologically, haematologically and perceptually to exercise under heat stress compared to females with no history of breast cancer (CON). Methods: Twenty-one (9 BCS, 12 CON females (age; 54 ± 7years, stature; 167 ± 6cm, body mass; 68.1 ± 7.62kg, body fat; 30.9 ± 3.8%) completed a warm (25°C, 50% relative humidity, RH) and hot (35°C, 50%RH) trial in a repeated-measures crossover design. Trials consisted of 30-minutes of rest, 30-minutes of walking at 4-metabolic equivalents, and a 6-minute walk test (6MWT). Physiological measurements (core temperature (Tre), skin temperature (Tskin), heart rate (HR), sweat analysis) and perceptual rating scales (ratings of perceived exertion, thermal sensation [whole body and localized] and thermal comfort) were taken at 5 and 10-minute intervals throughout, respectively. Venous blood samples were taken before and after to assess; IL-6, IL-10, CRP, IFN-γ, and TGF-β1. Results: All physiological markers were higher during the 35°C vs. 25°C trial; Tre (~0.25°C, p = 0.002), Tskin (~3.8°C, p<0.001), HR (~12 beats.min-1, p=0.023) and whole-body sweat rate (~0.4 L.hr-1, p<0.001), with no difference observed between groups in either condition (p>0.05). Both groups covered a greater 6MWT distance in 25°C vs. 35°C (by ~200m; p=0.003). Nevertheless, the control group covered more distance than BCS, regardless of environmental temperature (by ~400m, p=0.03). Conclusion: Thermoregulation was not disadvantaged in BCS compared to controls during moderate-intensity exercise under heat stress. However, self-paced exercise performance was reduced for BCS regardless of environmental temperature.
Original languageEnglish
Article numbere14968
Pages (from-to)1-16
Number of pages16
JournalPhysiological Reports
Volume9
DOIs
Publication statusPublished - 22 Jul 2021

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This is an open access article under the terms of the Creative Commo ns Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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