The effect of thiomersal, benzalkonium chloride and ethylenediaminetetraacetic acid (EDTA) on the nasal mucociliary clearance of healthy volunteers has been investigated using a modified saccharin test and gamma scintigraphy concomitantly. A significant correlation was found between the two techniques. Using each subject as his/her own control, none of the preservatives significantly altered the rate of clearance or proportion cleared from the nasal cavity after the administration of a single dose. This result is at variance with some in-vitro findings.
|Number of pages||6|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - 12 Apr 1991|
Lansley, A., Marriott, C., Martin, G. P., Bond, S. W., Greaves, J. L., & Wilson, C. G. (1991). The use of a radiolabelled saccharin solution to monitor the effect of the preservatives thiomersal, benzalkonium chloride and EDTA on human nasal clearance. Journal of Pharmacy and Pharmacology, 43(3), 180-185. https://doi.org/10.1111/j.2042-7158.1991.tb06662.x