TY - JOUR
T1 - The use of a radiolabelled saccharin solution to monitor the effect of the preservatives thiomersal, benzalkonium chloride and EDTA on human nasal clearance
AU - Lansley, Alison
AU - Marriott, Christopher
AU - Martin, Gary P.
AU - Bond, S.W.
AU - Greaves, Jane L.
AU - Wilson, Clive G.
PY - 1991/4/12
Y1 - 1991/4/12
N2 - The effect of thiomersal, benzalkonium chloride and ethylenediaminetetraacetic acid (EDTA) on the nasal mucociliary clearance of healthy volunteers has been investigated using a modified saccharin test and gamma scintigraphy concomitantly. A significant correlation was found between the two techniques. Using each subject as his/her own control, none of the preservatives significantly altered the rate of clearance or proportion cleared from the nasal cavity after the administration of a single dose. This result is at variance with some in-vitro findings.
AB - The effect of thiomersal, benzalkonium chloride and ethylenediaminetetraacetic acid (EDTA) on the nasal mucociliary clearance of healthy volunteers has been investigated using a modified saccharin test and gamma scintigraphy concomitantly. A significant correlation was found between the two techniques. Using each subject as his/her own control, none of the preservatives significantly altered the rate of clearance or proportion cleared from the nasal cavity after the administration of a single dose. This result is at variance with some in-vitro findings.
U2 - 10.1111/j.2042-7158.1991.tb06662.x
DO - 10.1111/j.2042-7158.1991.tb06662.x
M3 - Article
SN - 0022-3573
VL - 43
SP - 180
EP - 185
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 3
ER -