The time course of endogenous erythropoietin, IL-6, and TNFα in response to acute hypoxic exposures

G. Turner, Oliver Gibson, Peter Watt, J.S.M. Pringle, Alan Richardson, Neil Maxwell

Research output: Contribution to journalArticle

Abstract

Erythropoietin (EPO) rapidly decreases on return to sea level (SL) after chronic altitude exposure. Acute hypoxia may provide an additional stimulus to prevent the decline in EPO. Pro-inflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα), have been shown to inhibit EPO production. Optimal normobaric hypoxic exposure has not been established; therefore, investigation of methods eliciting the greatest response in EPO, to limit physiological stress is required. Eight males (age 27±4 yrs, body mass 77.5±9.0 kg, height 179±6 cm) performed four passive exposures to different normobaric hypoxic severities [FiO 2:0.209 (SL), FiO2:~0.135 (3,600 m), FiO2:~0.125 (4,200 m) and FiO2:~0.115 (4,800 m)] in a hypoxic chamber for 2 h. Venous blood was drawn pre-exposure and then at 1, 2, 4, 6 and 8 h to determine erythropoietin concentration ([EPO]), IL-6 and TNFα. During 4,200 m and 4,800 m [EPO] increased from 5.9±1.5 to 8.1±1.5 mU/mL (P=0.009) and 6.0±1.4 to 8.9±2.0 mU/mL (P=0.037), respectively, with [EPO] increase peaking at 4h (2h post-exposure). There were no differences in IL-6 or TNFα during, or post-exposure. Increased [EPO] was found 2 h post-hypoxic exposure as result of 2 h of normobaric hypoxia ≥4,200 m. There was no dose-response relationship in [EPO] between simulated hypoxia severities.
Original languageEnglish
Pages (from-to)714-723
Number of pages10
JournalScandinavian Journal of Medicine and Science in Sports
Volume27
Issue number7
DOIs
Publication statusPublished - 17 May 2016

Bibliographical note

This is the peer reviewed version of the following article: Turner, G., Gibson, O. R., Watt, P. W., Pringle, J. S. M., Richardson, A. J. and Maxwell, N. S. (2016), The time course of endogenous erythropoietin, IL-6, and TNFα in response to acute hypoxic exposures. Scandinavian Journal of Medicine & Science in Sports, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/sms.12700/abstract?campaign=wolearlyview. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

  • Hypoxia
  • EPO
  • altitude
  • cytokines
  • inflammation

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