The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Marta Falcinelli, Premal H. Thaker, Susan Lutgendorf, Suzanne Conzen, Renee Flaherty, Melanie Flint

Research output: Contribution to journalArticlepeer-review

Abstract

The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.
Original languageEnglish
JournalCancer Research
DOIs
Publication statusPublished - 15 Jul 2021

Keywords

  • Stress
  • cancer
  • initiation

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