The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Marta Falcinelli; Premal H. Thaker; Susan Lutgendorf; Suzanne Conzen; Renee Flaherty; Melanie Flint

doi:10.1158/0008-5472.CAN-21-0684

The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Marta Falcinelli, Premal H. Thaker, Susan Lutgendorf, Suzanne Conzen, Renee Flaherty, Melanie Flint

Centre for Lifelong Health

Research output: Contribution to journal › Article › peer-review

Abstract

The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

Original language	English
Pages (from-to)	5131-5140
Number of pages	10
Journal	Cancer Research
Volume	81
Issue number	20
DOIs	https://doi.org/10.1158/0008-5472.CAN-21-0684
Publication status	Published - 15 Jul 2021

Bibliographical note

Funding Information:
Acknowledgments: This work has been partially supported by R01CA246540 and R01CA193249 (SL).

Keywords

Stress
cancer
initiation

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10.1158/0008-5472.CAN-21-0684

Stress_cancer_initiationR3SUBMISSION (1)Accepted author manuscript, 337 KB

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T2 - clinical relevance and potential molecular mechanisms

AU - Falcinelli, Marta

AU - Thaker, Premal H.

AU - Lutgendorf, Susan

AU - Conzen, Suzanne

AU - Flaherty, Renee

AU - Flint, Melanie

N1 - Funding Information: Acknowledgments: This work has been partially supported by R01CA246540 and R01CA193249 (SL).

PY - 2021/7/15

Y1 - 2021/7/15

N2 - The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

AB - The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

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KW - cancer

KW - initiation

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DO - 10.1158/0008-5472.CAN-21-0684

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ER -

The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Abstract

Bibliographical note

Keywords

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