The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models

Maike Wolters; Carmen Dering; Alfonso Siani; Paola Russo; Jaakko Kaprio; Patrizia Rise; Luis A. Moreno; Stefaan De Henauw; Kirsten Mehlig; Yannis Pitsiladis; Toomas Veidebaum; Denés Molnár; Michael Tornaritis; Licia Iacoviello; Claudio Galli; Ronja Foraita; Claudia Börnhorst

doi:10.1371/journal.pone.0181485

The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models

Maike Wolters, Carmen Dering, Alfonso Siani, Paola Russo, Jaakko Kaprio, Patrizia Rise, Luis A. Moreno, Stefaan De Henauw, Kirsten Mehlig, Yannis Pitsiladis, Toomas Veidebaum, Denés Molnár, Michael Tornaritis, Licia Iacoviello, Claudio Galli, Ronja Foraita, Claudia Börnhorst

Research output: Contribution to journal › Article › peer-review

Abstract

The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP.

Original language	English
Journal	PLoS ONE
Volume	12
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0181485
Publication status	Published - 21 Jul 2017

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© 2017 Wolters et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Wolters, M., Dering, C., Siani, A., Russo, P., Kaprio, J., Rise, P., Moreno, L. A., De Henauw, S., Mehlig, K., Pitsiladis, Y., Veidebaum, T., Molnár, D., Tornaritis, M., Iacoviello, L., Galli, C., Foraita, R., & Börnhorst, C. (2017). The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models. PLoS ONE, 12(7). https://doi.org/10.1371/journal.pone.0181485

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title = "The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models",

abstract = "The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP.",

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Wolters, M, Dering, C, Siani, A, Russo, P, Kaprio, J, Rise, P, Moreno, LA, De Henauw, S, Mehlig, K, Pitsiladis, Y, Veidebaum, T, Molnár, D, Tornaritis, M, Iacoviello, L, Galli, C, Foraita, R & Börnhorst, C 2017, 'The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models', PLoS ONE, vol. 12, no. 7. https://doi.org/10.1371/journal.pone.0181485

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T1 - The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models

AU - Wolters, Maike

AU - Dering, Carmen

AU - Siani, Alfonso

AU - Russo, Paola

AU - Kaprio, Jaakko

AU - Rise, Patrizia

AU - Moreno, Luis A.

AU - De Henauw, Stefaan

AU - Mehlig, Kirsten

AU - Pitsiladis, Yannis

AU - Veidebaum, Toomas

AU - Molnár, Denés

AU - Tornaritis, Michael

AU - Iacoviello, Licia

AU - Galli, Claudio

AU - Foraita, Ronja

AU - Börnhorst, Claudia

N1 - © 2017 Wolters et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2017/7/21

Y1 - 2017/7/21

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AB - The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP.

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DO - 10.1371/journal.pone.0181485

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JF - PLoS ONE

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The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children - Analyses based on path models

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