The metastability of human UDP-galactose 4 '-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

Angel L. Pey; Esperanza Padin-Gonzalez; David Timson; Noel Mesa-Torres

The metastability of human UDP-galactose 4 '-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

Angel L. Pey
, Esperanza Padin-Gonzalez
, David Timson
, Noel Mesa-Torres

University of Brighton

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	103-114
Number of pages	12
Journal	Archives of Biochemistry and Biophysics
Volume	562
Publication status	Published - 15 Nov 2014

Keywords

Protein conformational stability
Protein dynamics
Protein aggregation
Proteolysis
Type III galactosemia
Ligand binding

Cite this

@article{0a438a0973fb41a18a0e7d9877a4a3b8,

title = "The metastability of human UDP-galactose 4 '-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding",

keywords = "Protein conformational stability, Protein dynamics, Protein aggregation, Proteolysis, Type III galactosemia, Ligand binding",

author = "Pey, \{Angel L.\} and Esperanza Padin-Gonzalez and David Timson and Noel Mesa-Torres",

year = "2014",

month = nov,

day = "15",

language = "English",

volume = "562",

pages = "103--114",

journal = "Archives of Biochemistry and Biophysics",

issn = "0003-9861",

}

The metastability of human UDP-galactose 4 '-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding. / Pey, Angel L.; Padin-Gonzalez, Esperanza; Timson, David et al.
In: Archives of Biochemistry and Biophysics, Vol. 562, 15.11.2014, p. 103-114.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The metastability of human UDP-galactose 4 '-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

AU - Pey, Angel L.

AU - Padin-Gonzalez, Esperanza

AU - Timson, David

AU - Mesa-Torres, Noel

PY - 2014/11/15

Y1 - 2014/11/15

KW - Protein conformational stability

KW - Protein dynamics

KW - Protein aggregation

KW - Proteolysis

KW - Type III galactosemia

KW - Ligand binding

M3 - Article

SN - 0003-9861

VL - 562

SP - 103

EP - 114

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

ER -