The human gut virome: form and function

Lesley Ogilvie, Brian Jones

Research output: Contribution to journalArticle

Abstract

Advances in next generation sequencing technologies and the application of metagenomic approaches have fuelled an exponential increase in our understanding of the human gut microbiome. These approaches are now also illuminating features of the diverse and abundant collection of viruses (termed the virome) subsisting with the microbial ecosystems residing within the human holobiont. Here we focus on the current and emerging knowledge of the human gut virome, with a particular focus on viruses infecting bacteria (bacteriophage or phage), which are a dominant component of this viral community. We summarise current insights regarding the form and function of this ‘human gut phageome’ and highlight promising avenues for future research. In doing so we discuss the potential for phage to drive ecological functioning and evolutionary change within this important microbial ecosystem, their contribution to modulation of host-microbiome interactions and stability of the community as a whole, as well as the potential role of the phageome in human health and disease. We also consider the emerging concepts of a ‘core healthy gut phageome’ and the putative existence of ‘viral enterotypes’ and ‘viral dysbiosis’.
Original languageEnglish
Pages (from-to)351-362
Number of pages12
JournalEmerging Topics in Life Sciences
Volume1
Issue number4
DOIs
Publication statusPublished - 30 Nov 2017

Fingerprint

Bacteriophages
Microbiota
Ecosystem
Dysbiosis
Viruses
Metagenomics
Viral Structures
Technology
Bacteria
Health
Gastrointestinal Microbiome

Bibliographical note

This is the not the final peer-reviewed Version of Record. The VoR can be found at: http://www.emergtoplifesci.org/content/1/4/351.article-info

Keywords

  • bacteriophage
  • human gut virome
  • human gut phageome

Cite this

Ogilvie, Lesley ; Jones, Brian. / The human gut virome: form and function. In: Emerging Topics in Life Sciences. 2017 ; Vol. 1, No. 4. pp. 351-362.
@article{aec033469f134eeeafd0a58717395ae3,
title = "The human gut virome: form and function",
abstract = "Advances in next generation sequencing technologies and the application of metagenomic approaches have fuelled an exponential increase in our understanding of the human gut microbiome. These approaches are now also illuminating features of the diverse and abundant collection of viruses (termed the virome) subsisting with the microbial ecosystems residing within the human holobiont. Here we focus on the current and emerging knowledge of the human gut virome, with a particular focus on viruses infecting bacteria (bacteriophage or phage), which are a dominant component of this viral community. We summarise current insights regarding the form and function of this ‘human gut phageome’ and highlight promising avenues for future research. In doing so we discuss the potential for phage to drive ecological functioning and evolutionary change within this important microbial ecosystem, their contribution to modulation of host-microbiome interactions and stability of the community as a whole, as well as the potential role of the phageome in human health and disease. We also consider the emerging concepts of a ‘core healthy gut phageome’ and the putative existence of ‘viral enterotypes’ and ‘viral dysbiosis’.",
keywords = "bacteriophage, human gut virome, human gut phageome",
author = "Lesley Ogilvie and Brian Jones",
note = "This is the not the final peer-reviewed Version of Record. The VoR can be found at: http://www.emergtoplifesci.org/content/1/4/351.article-info",
year = "2017",
month = "11",
day = "30",
doi = "10.1042/ETLS20170039",
language = "English",
volume = "1",
pages = "351--362",
journal = "Emerging Topics in Life Sciences",
issn = "2397-8554",
number = "4",

}

The human gut virome: form and function. / Ogilvie, Lesley; Jones, Brian.

In: Emerging Topics in Life Sciences, Vol. 1, No. 4, 30.11.2017, p. 351-362.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The human gut virome: form and function

AU - Ogilvie, Lesley

AU - Jones, Brian

N1 - This is the not the final peer-reviewed Version of Record. The VoR can be found at: http://www.emergtoplifesci.org/content/1/4/351.article-info

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Advances in next generation sequencing technologies and the application of metagenomic approaches have fuelled an exponential increase in our understanding of the human gut microbiome. These approaches are now also illuminating features of the diverse and abundant collection of viruses (termed the virome) subsisting with the microbial ecosystems residing within the human holobiont. Here we focus on the current and emerging knowledge of the human gut virome, with a particular focus on viruses infecting bacteria (bacteriophage or phage), which are a dominant component of this viral community. We summarise current insights regarding the form and function of this ‘human gut phageome’ and highlight promising avenues for future research. In doing so we discuss the potential for phage to drive ecological functioning and evolutionary change within this important microbial ecosystem, their contribution to modulation of host-microbiome interactions and stability of the community as a whole, as well as the potential role of the phageome in human health and disease. We also consider the emerging concepts of a ‘core healthy gut phageome’ and the putative existence of ‘viral enterotypes’ and ‘viral dysbiosis’.

AB - Advances in next generation sequencing technologies and the application of metagenomic approaches have fuelled an exponential increase in our understanding of the human gut microbiome. These approaches are now also illuminating features of the diverse and abundant collection of viruses (termed the virome) subsisting with the microbial ecosystems residing within the human holobiont. Here we focus on the current and emerging knowledge of the human gut virome, with a particular focus on viruses infecting bacteria (bacteriophage or phage), which are a dominant component of this viral community. We summarise current insights regarding the form and function of this ‘human gut phageome’ and highlight promising avenues for future research. In doing so we discuss the potential for phage to drive ecological functioning and evolutionary change within this important microbial ecosystem, their contribution to modulation of host-microbiome interactions and stability of the community as a whole, as well as the potential role of the phageome in human health and disease. We also consider the emerging concepts of a ‘core healthy gut phageome’ and the putative existence of ‘viral enterotypes’ and ‘viral dysbiosis’.

KW - bacteriophage

KW - human gut virome

KW - human gut phageome

U2 - 10.1042/ETLS20170039

DO - 10.1042/ETLS20170039

M3 - Article

VL - 1

SP - 351

EP - 362

JO - Emerging Topics in Life Sciences

JF - Emerging Topics in Life Sciences

SN - 2397-8554

IS - 4

ER -