The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study

R.G. Riley; K.L. Green; John Smart; J. Tsibouklis; J.A. Davis; F. Hampson; P.W. Dettmar; W.R. Wilber

doi:10.1016/S0142-9612(00)00369-0

The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study

R.G. Riley, K.L. Green, John Smart, J. Tsibouklis, J.A. Davis, F. Hampson, P.W. Dettmar, W.R. Wilber

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.

Original language	English
Pages (from-to)	1861-1867
Number of pages	7
Journal	Biomaterials
Volume	22
Issue number	13
DOIs	https://doi.org/10.1016/S0142-9612(00)00369-0
Publication status	Published - Jul 2001

Keywords

14C-poly(acrylic acid)
In vivo
Polymer retention
Mucoadhesion

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http://www.sciencedirect.com/science/article/pii/S0142961200003690Licence: Unspecified

Cite this

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abstract = "The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.",

keywords = "14C-poly(acrylic acid), In vivo, Polymer retention, Mucoadhesion",

author = "R.G. Riley and K.L. Green and John Smart and J. Tsibouklis and J.A. Davis and F. Hampson and P.W. Dettmar and W.R. Wilber",

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AU - Riley, R.G.

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AU - Tsibouklis, J.

AU - Davis, J.A.

AU - Hampson, F.

AU - Dettmar, P.W.

AU - Wilber, W.R.

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AB - The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.

KW - 14C-poly(acrylic acid)

KW - In vivo

KW - Polymer retention

KW - Mucoadhesion

U2 - 10.1016/S0142-9612(00)00369-0

DO - 10.1016/S0142-9612(00)00369-0

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SP - 1861

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JO - Biomaterials

JF - Biomaterials

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The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study

Abstract

Keywords

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