The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study

R.G. Riley, K.L. Green, John Smart, J. Tsibouklis, J.A. Davis, F. Hampson, P.W. Dettmar, W.R. Wilber

Research output: Contribution to journalArticle

Abstract

The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.
Original languageEnglish
Pages (from-to)1861-1867
Number of pages7
JournalBiomaterials
Volume22
Issue number13
DOIs
Publication statusPublished - Jul 2001

Keywords

  • 14C-poly(acrylic acid)
  • In vivo
  • Polymer retention
  • Mucoadhesion

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    Riley, R. G., Green, K. L., Smart, J., Tsibouklis, J., Davis, J. A., Hampson, F., Dettmar, P. W., & Wilber, W. R. (2001). The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study. Biomaterials, 22(13), 1861-1867. https://doi.org/10.1016/S0142-9612(00)00369-0