The future of genomic research in athletic performance and adaptation to training

Guan Wang; M. Tanaka; Nir Eynon; Kathryn N. North; A.G. Williams; Malcolm Collins; Colin N. Moran; Steven L. Britton; Noriyuki Fuku; Euan Ashley; Vassilis Klissouras; Alejandro Lucia; Ildus I. Ahmetov; Eco de Geus; Mohammed Alsayrafi; Yannis Pitsiladis

doi:10.1159/000445241

The future of genomic research in athletic performance and adaptation to training

Guan Wang, M. Tanaka, Nir Eynon, Kathryn N. North, A.G. Williams, Malcolm Collins, Colin N. Moran, Steven L. Britton, Noriyuki Fuku, Euan Ashley, Vassilis Klissouras, Alejandro Lucia, Ildus I. Ahmetov, Eco de Geus, Mohammed Alsayrafi, Yannis Pitsiladis

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter

Abstract

Despite numerous attempts to discover genetic variants associated with elite athletic performance, an individual's trainability and injury predisposition, there has been limited progress to date. Past reliance on candidate gene studies focusing predominantly on genotyping a limited number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related genetic mechanisms. Large, collaborative projects with sound experimental designs (e.g. clearly defined phenotypes, considerations and controls for sources of variability, and necessary replications) are required to produce meaningful results, especially when a hypothesis-free approach is used. It remains to be determined whether the novel approaches under current implementation will result in findings with real practical significance. This review will briefly summarize current and future directions in exercise genetics and genomics.

Original language	English
Title of host publication	Genetics and sports
Editors	M. Posthumus, M. Collins
Place of Publication	Basel, Switzerland
Publisher	Karger
Pages	55-67
Number of pages	13
Volume	61
ISBN (Print)	9783318030112
DOIs	https://doi.org/10.1159/000445241
Publication status	Published - 30 Jun 2016

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Wang, G., Tanaka, M., Eynon, N., North, K. N., Williams, A. G., Collins, M., Moran, C. N., Britton, S. L., Fuku, N., Ashley, E., Klissouras, V., Lucia, A., Ahmetov, I. I., Geus, E. D., Alsayrafi, M., & Pitsiladis, Y. (2016). The future of genomic research in athletic performance and adaptation to training. In M. Posthumus, & M. Collins (Eds.), Genetics and sports (Vol. 61, pp. 55-67). Karger. https://doi.org/10.1159/000445241

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abstract = "Despite numerous attempts to discover genetic variants associated with elite athletic performance, an individual's trainability and injury predisposition, there has been limited progress to date. Past reliance on candidate gene studies focusing predominantly on genotyping a limited number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related genetic mechanisms. Large, collaborative projects with sound experimental designs (e.g. clearly defined phenotypes, considerations and controls for sources of variability, and necessary replications) are required to produce meaningful results, especially when a hypothesis-free approach is used. It remains to be determined whether the novel approaches under current implementation will result in findings with real practical significance. This review will briefly summarize current and future directions in exercise genetics and genomics.",

author = "Guan Wang and M. Tanaka and Nir Eynon and North, {Kathryn N.} and A.G. Williams and Malcolm Collins and Moran, {Colin N.} and Britton, {Steven L.} and Noriyuki Fuku and Euan Ashley and Vassilis Klissouras and Alejandro Lucia and Ahmetov, {Ildus I.} and Geus, {Eco de} and Mohammed Alsayrafi and Yannis Pitsiladis",

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Wang, G, Tanaka, M, Eynon, N, North, KN, Williams, AG, Collins, M, Moran, CN, Britton, SL, Fuku, N, Ashley, E, Klissouras, V, Lucia, A, Ahmetov, II, Geus, ED, Alsayrafi, M & Pitsiladis, Y 2016, The future of genomic research in athletic performance and adaptation to training. in M Posthumus & M Collins (eds), Genetics and sports. vol. 61, Karger, Basel, Switzerland, pp. 55-67. https://doi.org/10.1159/000445241

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T1 - The future of genomic research in athletic performance and adaptation to training

AU - Wang, Guan

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AU - North, Kathryn N.

AU - Williams, A.G.

AU - Collins, Malcolm

AU - Moran, Colin N.

AU - Britton, Steven L.

AU - Fuku, Noriyuki

AU - Ashley, Euan

AU - Klissouras, Vassilis

AU - Lucia, Alejandro

AU - Ahmetov, Ildus I.

AU - Geus, Eco de

AU - Alsayrafi, Mohammed

AU - Pitsiladis, Yannis

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AB - Despite numerous attempts to discover genetic variants associated with elite athletic performance, an individual's trainability and injury predisposition, there has been limited progress to date. Past reliance on candidate gene studies focusing predominantly on genotyping a limited number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related genetic mechanisms. Large, collaborative projects with sound experimental designs (e.g. clearly defined phenotypes, considerations and controls for sources of variability, and necessary replications) are required to produce meaningful results, especially when a hypothesis-free approach is used. It remains to be determined whether the novel approaches under current implementation will result in findings with real practical significance. This review will briefly summarize current and future directions in exercise genetics and genomics.

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BT - Genetics and sports

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A2 - Collins, M.

PB - Karger

CY - Basel, Switzerland

ER -

The future of genomic research in athletic performance and adaptation to training

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