The effectiveness and safety of cannabis/cannabinoids for painful diabetic neuropathy: A systematic review

Mariam Alessa, Deborah Whitham, Christopher Morriss-Roberts

Research output: Contribution to journalArticle


Objective: To evaluate the effectiveness and safety of cannabis/cannabinoids for painful diabetic neuropathy (PDN).
Design: Systematic review of interventional studies.
Data Source: Medline, PubMed, The Cochrane Central Register of Controlled Trials (CENTRAL), AMED, PsycINFO,
CINAHL, Web of Science and ScienceDirect, along with references from identified papers and grey literature
search up to September 2017. Terms used were combined as follows: (marijuana OR marihuana OR cannabis OR
cannabinoids) AND (painful neuropathy OR neuropathic pain) AND (Diabetes).
Study Selection: Studies of cannabis/cannabinoids, in adult participants diagnosed with PDN. Validity of trials was
assessed using the Cochrane Collaboration’s tool for assessing risk of bias.
Data Synthesis: Five studies that fit the inclusion criteria were identified.
Conclusion: Cannabis and cannabinoids provide an interesting treatment choice for PDN. Further high-quality studies with larger sample sizes and longer durations are required to assess its long-term effectiveness and safety as well as the best form of drug delivery.
Original languageEnglish
Pages (from-to)9-20
Number of pages11
JournalGlobal Scientific Research Journal Diabetes
Issue number1
Publication statusPublished - 27 Jun 2018


Bibliographical note

© 2018 Mariam Alessa et al., This is an open access article distributed under the Creative Commons Attribution License, which permits wwunrestricted use, distribution, and reproduction in any medium, provided
the original work is properly cited.


  • Diabetes
  • cannabis
  • cannabinoids
  • painful peripheral neuropathy
  • PDPN
  • DPN
  • interventional studies
  • peripheral neuropathy
  • neuropathic pain
  • neuropathy
  • CBD
  • PDN

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