The effect of some preservatives used in nasal preparations on mucociliary clearance

Alison Lansley, Claire Marriott, G.P. Martin, S.W. Bond

Research output: Contribution to journalArticle

Abstract

The effect of methyl-ρ-hydroxybenzoate, propyl-ρ-hydroxybenzoate, chlorbutol, chlorocresol, EDTA, benzalkonium chloride, chlorhexidine, phenylmercuric nitrate and phenylmercuric borate on mucociliary transport rate of the frog palate has been examined. Following a variable number of applications all these preservatives halted transport, the first three reversibly. However, applications of thiomersal (0·01%) were well tolerated. The frog palate possesses a ciliated epithelium protected by mucus, since some of our findings are at variance with those previously reported results where the protective effect of mucus was negligible in the in-vitro model (usually trachea) employed, it would appear that the contribution of mucus to effective mucociliary clearance should not be underestimated
Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume41
Issue number3
DOIs
Publication statusPublished - 31 Mar 1989

Fingerprint Dive into the research topics of 'The effect of some preservatives used in nasal preparations on mucociliary clearance'. Together they form a unique fingerprint.

  • Cite this