TY - JOUR
T1 - The effect of some preservatives used in nasal preparations on mucociliary clearance
AU - Lansley, Alison
AU - Marriott, Claire
AU - Martin, G.P.
AU - Bond, S.W.
PY - 1989/3/31
Y1 - 1989/3/31
N2 - The effect of methyl-ρ-hydroxybenzoate, propyl-ρ-hydroxybenzoate, chlorbutol, chlorocresol, EDTA, benzalkonium chloride, chlorhexidine, phenylmercuric nitrate and phenylmercuric borate on mucociliary transport rate of the frog palate has been examined. Following a variable number of applications all these preservatives halted transport, the first three reversibly. However, applications of thiomersal (0·01%) were well tolerated. The frog palate possesses a ciliated epithelium protected by mucus, since some of our findings are at variance with those previously reported results where the protective effect of mucus was negligible in the in-vitro model (usually trachea) employed, it would appear that the contribution of mucus to effective mucociliary clearance should not be underestimated
AB - The effect of methyl-ρ-hydroxybenzoate, propyl-ρ-hydroxybenzoate, chlorbutol, chlorocresol, EDTA, benzalkonium chloride, chlorhexidine, phenylmercuric nitrate and phenylmercuric borate on mucociliary transport rate of the frog palate has been examined. Following a variable number of applications all these preservatives halted transport, the first three reversibly. However, applications of thiomersal (0·01%) were well tolerated. The frog palate possesses a ciliated epithelium protected by mucus, since some of our findings are at variance with those previously reported results where the protective effect of mucus was negligible in the in-vitro model (usually trachea) employed, it would appear that the contribution of mucus to effective mucociliary clearance should not be underestimated
U2 - 10.1111/j.2042-7158.1989.tb06420.x
DO - 10.1111/j.2042-7158.1989.tb06420.x
M3 - Article
SN - 0022-3573
VL - 41
SP - 156
EP - 159
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 3
ER -