The effect of protein binding on ibuprofen adsorption to activated carbons

M. Melillo; Gary Phillips; Graham Davies; Andrew Lloyd; S.R. Tennison; O.P. Kozynchenko; Sergey Mikhalovsky

doi:10.1016/j.carbon.2003.12.064

The effect of protein binding on ibuprofen adsorption to activated carbons

M. Melillo, Gary Phillips, Graham Davies, Andrew Lloyd, S.R. Tennison, O.P. Kozynchenko, Sergey Mikhalovsky

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

The potential of a range of polymer-based activated carbons to remove a non-steroidal anti-inflammatory drug ibuprofen from protein containing and protein-free solutions was studied. The adsorption capacity of five activated carbons produced from phenol–formaldehyde resin precursors (MAST Carbon Ltd) was compared to a cellulose coated activated carbon Norit RBX used in a commercial Adsorba®300C haemoperfusion column (Gambro). Ibuprofen adsorption was studied in batch experiments over 24 h at pH=7.6 and 25 °C and adsorption equilibrium data were correlated with the Langmuir and Freundlich equations. Results showed that uncoated mesoporous MAST carbons can remove ibuprofen from model solutions both in the presence and absence of serum albumin. Ibuprofen is a highly protein-bound drug and the presence of serum albumin significantly affects the adsorption of ibuprofen by cellulose-coated microporous carbon used in Adsorba®300C column.

Original language	English
Pages (from-to)	565-571
Number of pages	7
Journal	Carbon
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/j.carbon.2003.12.064
Publication status	Published - 2004

Keywords

Activated carbon
Adsorption
Ibuprofen
Blood purification

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title = "The effect of protein binding on ibuprofen adsorption to activated carbons",

abstract = "The potential of a range of polymer-based activated carbons to remove a non-steroidal anti-inflammatory drug ibuprofen from protein containing and protein-free solutions was studied. The adsorption capacity of five activated carbons produced from phenol–formaldehyde resin precursors (MAST Carbon Ltd) was compared to a cellulose coated activated carbon Norit RBX used in a commercial Adsorba{\textregistered}300C haemoperfusion column (Gambro). Ibuprofen adsorption was studied in batch experiments over 24 h at pH=7.6 and 25 °C and adsorption equilibrium data were correlated with the Langmuir and Freundlich equations. Results showed that uncoated mesoporous MAST carbons can remove ibuprofen from model solutions both in the presence and absence of serum albumin. Ibuprofen is a highly protein-bound drug and the presence of serum albumin significantly affects the adsorption of ibuprofen by cellulose-coated microporous carbon used in Adsorba{\textregistered}300C column.",

keywords = "Activated carbon, Adsorption, Ibuprofen, Blood purification",

author = "M. Melillo and Gary Phillips and Graham Davies and Andrew Lloyd and S.R. Tennison and O.P. Kozynchenko and Sergey Mikhalovsky",

year = "2004",

doi = "10.1016/j.carbon.2003.12.064",

language = "English",

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pages = "565--571",

journal = "Carbon",

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TY - JOUR

T1 - The effect of protein binding on ibuprofen adsorption to activated carbons

AU - Melillo, M.

AU - Phillips, Gary

AU - Davies, Graham

AU - Lloyd, Andrew

AU - Tennison, S.R.

AU - Kozynchenko, O.P.

AU - Mikhalovsky, Sergey

PY - 2004

Y1 - 2004

N2 - The potential of a range of polymer-based activated carbons to remove a non-steroidal anti-inflammatory drug ibuprofen from protein containing and protein-free solutions was studied. The adsorption capacity of five activated carbons produced from phenol–formaldehyde resin precursors (MAST Carbon Ltd) was compared to a cellulose coated activated carbon Norit RBX used in a commercial Adsorba®300C haemoperfusion column (Gambro). Ibuprofen adsorption was studied in batch experiments over 24 h at pH=7.6 and 25 °C and adsorption equilibrium data were correlated with the Langmuir and Freundlich equations. Results showed that uncoated mesoporous MAST carbons can remove ibuprofen from model solutions both in the presence and absence of serum albumin. Ibuprofen is a highly protein-bound drug and the presence of serum albumin significantly affects the adsorption of ibuprofen by cellulose-coated microporous carbon used in Adsorba®300C column.

AB - The potential of a range of polymer-based activated carbons to remove a non-steroidal anti-inflammatory drug ibuprofen from protein containing and protein-free solutions was studied. The adsorption capacity of five activated carbons produced from phenol–formaldehyde resin precursors (MAST Carbon Ltd) was compared to a cellulose coated activated carbon Norit RBX used in a commercial Adsorba®300C haemoperfusion column (Gambro). Ibuprofen adsorption was studied in batch experiments over 24 h at pH=7.6 and 25 °C and adsorption equilibrium data were correlated with the Langmuir and Freundlich equations. Results showed that uncoated mesoporous MAST carbons can remove ibuprofen from model solutions both in the presence and absence of serum albumin. Ibuprofen is a highly protein-bound drug and the presence of serum albumin significantly affects the adsorption of ibuprofen by cellulose-coated microporous carbon used in Adsorba®300C column.

KW - Activated carbon

KW - Adsorption

KW - Ibuprofen

KW - Blood purification

U2 - 10.1016/j.carbon.2003.12.064

DO - 10.1016/j.carbon.2003.12.064

M3 - Article

SN - 0008-6223

VL - 42

SP - 565

EP - 571

JO - Carbon

JF - Carbon

IS - 3

ER -

The effect of protein binding on ibuprofen adsorption to activated carbons

Abstract

Keywords

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