The effect of Microcarrier-delivered Keratinocytes and Single-stage Matriderm on Wound Contraction and Epithelialisation

S. Ray; B. Dheansa; Anthony Metcalfe; J.R. Sharpe

doi:10.1111/wrr.12114

The effect of Microcarrier-delivered Keratinocytes and Single-stage Matriderm on Wound Contraction and Epithelialisation

S. Ray, B. Dheansa, Anthony Metcalfe, J.R. Sharpe

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

Delayed burn wound healing is associated with scarring and contracture formation which may result in functional disability and psychological distress for patients. Specialist long-term management also has significant healthcare costs. The application of sprayed autologous keratinocytes (SAK) to accelerate burn wound healing is well established. The use of gelatin microcarrier beads (Cultisphere G) to culture and deliver autologous keratinocytes (AK) to a wound bed negates the use of murine feeder cells or proteolytic enzymes which may temporarily inhibit cell proliferation, attachment and migration. The aim of this pre-clinical study was to determine the effect of microcarrier-delivered keratinocytes and Matriderm (dermal regeneration template) on wound contraction and epithelialisation.

Original language	English
Journal	Wound Repair and Regeneration
Volume	21
Issue number	6
DOIs	https://doi.org/10.1111/wrr.12114
Publication status	Published - 30 Nov 2013

Bibliographical note

This is the peer reviewed version of the following article: 23rd Annual Meeting of the European Tissue Repair Society. Wound Repair and Regeneration, 21: A55–A88, which has been published in final form at 10.1111/wrr.12114. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Cite this

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title = "The effect of Microcarrier-delivered Keratinocytes and Single-stage Matriderm on Wound Contraction and Epithelialisation",

abstract = "Delayed burn wound healing is associated with scarring and contracture formation which may result in functional disability and psychological distress for patients. Specialist long-term management also has significant healthcare costs. The application of sprayed autologous keratinocytes (SAK) to accelerate burn wound healing is well established. The use of gelatin microcarrier beads (Cultisphere G) to culture and deliver autologous keratinocytes (AK) to a wound bed negates the use of murine feeder cells or proteolytic enzymes which may temporarily inhibit cell proliferation, attachment and migration. The aim of this pre-clinical study was to determine the effect of microcarrier-delivered keratinocytes and Matriderm (dermal regeneration template) on wound contraction and epithelialisation.",

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note = "This is the peer reviewed version of the following article: 23rd Annual Meeting of the European Tissue Repair Society. Wound Repair and Regeneration, 21: A55–A88, which has been published in final form at 10.1111/wrr.12114. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",

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AU - Sharpe, J.R.

N1 - This is the peer reviewed version of the following article: 23rd Annual Meeting of the European Tissue Repair Society. Wound Repair and Regeneration, 21: A55–A88, which has been published in final form at 10.1111/wrr.12114. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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N2 - Delayed burn wound healing is associated with scarring and contracture formation which may result in functional disability and psychological distress for patients. Specialist long-term management also has significant healthcare costs. The application of sprayed autologous keratinocytes (SAK) to accelerate burn wound healing is well established. The use of gelatin microcarrier beads (Cultisphere G) to culture and deliver autologous keratinocytes (AK) to a wound bed negates the use of murine feeder cells or proteolytic enzymes which may temporarily inhibit cell proliferation, attachment and migration. The aim of this pre-clinical study was to determine the effect of microcarrier-delivered keratinocytes and Matriderm (dermal regeneration template) on wound contraction and epithelialisation.

AB - Delayed burn wound healing is associated with scarring and contracture formation which may result in functional disability and psychological distress for patients. Specialist long-term management also has significant healthcare costs. The application of sprayed autologous keratinocytes (SAK) to accelerate burn wound healing is well established. The use of gelatin microcarrier beads (Cultisphere G) to culture and deliver autologous keratinocytes (AK) to a wound bed negates the use of murine feeder cells or proteolytic enzymes which may temporarily inhibit cell proliferation, attachment and migration. The aim of this pre-clinical study was to determine the effect of microcarrier-delivered keratinocytes and Matriderm (dermal regeneration template) on wound contraction and epithelialisation.

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DO - 10.1111/wrr.12114

M3 - Article

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JO - Wound Repair and Regeneration

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The effect of Microcarrier-delivered Keratinocytes and Single-stage Matriderm on Wound Contraction and Epithelialisation

Abstract

Bibliographical note

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