The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

Keyphrases

• Adenosine 100%
• PARP Inhibitor (PARPi) 100%
• Potent Inhibitor 100%
• Isoindolinone 66%
• IC50 Value 33%
• Piperazine 33%
• Adenosine Derivatives 33%
• Core Structure 33%
• Linker 33%
• Spacer Group 33%
• Methyl 33%
• Methyl Benzoate 33%
• Nitro 33%
• Acyl 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine 100%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 100%
• IC50 33%
• Piperazine 33%
• Adenosine Derivative 33%
• 2 Methylbenzoic Acid 33%
• Boron 10 33%