The current chemical utility of marine and terrestrial filamentous fungi in side-chain chemistry

A.C. Hunter

Research output: Contribution to journalArticle

Abstract

This review focuses on three aspects of the application of marine and terrestrial filamentous fungi to side-chain chemistry from 2000 to early 2006. The first section covers the generation of novel biologically active side-chain containing metabolites. This includes a range of antibiotic, cytotoxic and novel bioactive compounds. The second section discusses the use of these fungi both whole cell and lipases of fungal origin in the chemical modification of side-chains. Examples include reductive desymmetrization of pro-chiral ketones, dynamic kinetic resolution and unique reactions. The final section details the degradation of side-chains by fungi and includes lignin and steroid transformations for determination metabolism and the generation of new skeletal structure.
Original languageEnglish
Pages (from-to)665-677
Number of pages13
JournalCurrent Organic Chemistry
Volume11
Issue number8
Publication statusPublished - May 2007

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